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1996 2
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1999 2
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2008 2
2009 2
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2014 3
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48 results

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Page 1
Genetic Editing and Pharmacogenetics in Current And Future Therapy Of Neurocognitive Disorders.
Prendecki M, Kowalska M, Toton E, Kozubski W. Prendecki M, et al. Curr Alzheimer Res. 2020;17(3):238-258. doi: 10.2174/1567205017666200422152440. Curr Alzheimer Res. 2020. PMID: 32321403 Review.
The researchers investigate the effects of variants in multiple genes, such as ABCB1, ACE, CHAT, CHRNA7, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, CYP3A7, NR1I2, NR1I3, POR, PPAR, RXR, SLC22A1/2/5, SLC47A1, UGT1A6, UGT1A9 and UGT2B7, associated with numerous pathways …
The researchers investigate the effects of variants in multiple genes, such as ABCB1, ACE, CHAT, CHRNA7, CYP2C9, CYP2C19, CYP2D6, CYP …
Fetal hepatic drug elimination.
Ring JA, Ghabrial H, Ching MS, Smallwood RA, Morgan DJ. Ring JA, et al. Pharmacol Ther. 1999 Dec;84(3):429-45. doi: 10.1016/s0163-7258(99)00046-7. Pharmacol Ther. 1999. PMID: 10665839 Review.
Unlike rodent species, the human fetal liver has a significant capacity for drug metabolism. Of the oxidative enzymes, CYP3A7 accounts for up to 50% of total fetal hepatic cytochrome P450 content. Expression of this enzyme decreases dramatically after birth. CYP1A1 …
Unlike rodent species, the human fetal liver has a significant capacity for drug metabolism. Of the oxidative enzymes, CYP3A7 account …
Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis.
Sen A, Stark H. Sen A, et al. World J Gastroenterol. 2019 Jun 21;25(23):2846-2862. doi: 10.3748/wjg.v25.i23.2846. World J Gastroenterol. 2019. PMID: 31249444 Free PMC article. Review.
In this review, we discuss the role of some critical CYP isoforms (CYP1A1, CYP2D6, CYP2J2, CYP2R1, CYP3A5, CYP3A7, CYP4F3, CYP24A1, CYP26B1 and CYP27B1) in the pathogenesis or aetiology of ulcerative colitis concerning gene polymorphisms. ...
In this review, we discuss the role of some critical CYP isoforms (CYP1A1, CYP2D6, CYP2J2, CYP2R1, CYP3A5, CYP3A7, CYP4F3, CYP …
A review of the role of genetic testing in pain medicine.
Trescot AM, Faynboym S. Trescot AM, et al. Pain Physician. 2014 Sep-Oct;17(5):425-45. Pain Physician. 2014. PMID: 25247900 Free article. Review.
METHODS: This article discusses the specific pain implications of genetic variations in CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A7, OPRM1, OPRK1, OPRD1, COMT, GABA, UGT, MC1R, GCH1, ABCB1, P-glycoprotein, 5HTR1A, 5HTR2A, MTHFR, CACNA2D2, and 5-H …
METHODS: This article discusses the specific pain implications of genetic variations in CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2 …
CYP3A4 and pregnane X receptor humanized mice.
Gonzalez FJ. Gonzalez FJ. J Biochem Mol Toxicol. 2007;21(4):158-62. doi: 10.1002/jbt.20173. J Biochem Mol Toxicol. 2007. PMID: 17936928 Review.
In some cases, transgenic mice carrying the human genes are bred with null-mice to produce fully humanized mice. Mice expressing human CYP1A1, CYP1A2, CYP2E1, CYP2D6, CYP3A4, and CYP3A7 were generated and characterized. Studies with the CYP3A4-humanized (hCYP3A4) mo …
In some cases, transgenic mice carrying the human genes are bred with null-mice to produce fully humanized mice. Mice expressing human CYP1A …
Metabolism of deltamethrin and cis- and trans-permethrin by human expressed cytochrome P450 and carboxylesterase enzymes.
Hedges L, Brown S, MacLeod AK, Vardy A, Doyle E, Song G, Moreau M, Yoon M, Osimitz TG, Lake BG. Hedges L, et al. Xenobiotica. 2019 May;49(5):521-527. doi: 10.1080/00498254.2018.1474283. Epub 2018 Jun 4. Xenobiotica. 2019. PMID: 29779438
The metabolism of the pyrethroids deltamethrin (DLM), cis-permethrin (CPM) and trans-permethrin (TPM) was studied in human expressed cytochrome P450 (CYP) and carboxylesterase (CES) enzymes. DLM, CPM and TPM were metabolised by human CYP2B6 and CYP2C19, with the highest ap …
The metabolism of the pyrethroids deltamethrin (DLM), cis-permethrin (CPM) and trans-permethrin (TPM) was studied in human expressed cyto …
A review of developmental aspects of cytochrome P450.
Oesterheld JR. Oesterheld JR. J Child Adolesc Psychopharmacol. 1998;8(3):161-74. doi: 10.1089/cap.1998.8.161. J Child Adolesc Psychopharmacol. 1998. PMID: 9853690 Review.
These hepatic P450 CYPs come "on line" at different times during fetal and infant development, and each one is discussed in that temporal sequence. CYP3A7. the major fetal hepatic cytochrome, is present during organogenesis, and it is involved in steroid metabolism. …
These hepatic P450 CYPs come "on line" at different times during fetal and infant development, and each one is discussed in that temporal se …
Cytochrome P450 gene polymorphism and cancer.
Agundez JA. Agundez JA. Curr Drug Metab. 2004 Jun;5(3):211-24. doi: 10.2174/1389200043335621. Curr Drug Metab. 2004. PMID: 15180491 Review.
Human cytochrome P450 (CYP) enzymes play a key role in the metabolism of drugs and environmental chemicals. ...Here we review the findings obtained in these studies regarding CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2D6, CYP2E1, C …
Human cytochrome P450 (CYP) enzymes play a key role in the metabolism of drugs and environmental chemicals. ...Here we review the fin …
Heterotropic cooperativity in oxidation mediated by cytochrome p450.
Niwa T, Murayama N, Yamazaki H. Niwa T, et al. Curr Drug Metab. 2008 Jun;9(5):453-62. doi: 10.2174/138920008784746364. Curr Drug Metab. 2008. PMID: 18537580 Review.
Cytochrome P450s (P450 or CYPs) comprise a superfamily of enzymes that catalyze the oxidation of a wide variety of xenobiotic chemicals. ...Interestingly, recent studies have been shown that human P450 forms other than CYP3A4, such as CYP1A2, CYP2C8, CYP2C9, CYP2D6, …
Cytochrome P450s (P450 or CYPs) comprise a superfamily of enzymes that catalyze the oxidation of a wide variety of xenobiotic chemica …
48 results